XDH
Summary: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607633 Ensembl IDEnsembl:ENSG00000158125 HGNC IDHGNC:HGNC:12805 PHARMGKB IDPA37404 Map Location2p23.1 | |||||
GO terms in XDH
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IDA | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | TAS | GO:0006195 | purine nucleotide catabolic process |
| BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0007595 | lactation |
| BP | IBA | GO:0009115 | xanthine catabolic process |
Gene expression in normal tissue: XDH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XDH
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-74259 | Purine catabolism |
| reactome | R-HSA-8851680 | Butyrophilin (BTN) family interactions |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XDH
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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