YWHAH
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | MIM:113508 | Ensembl:ENSG00000128245 | HGNC:HGNC:12853 | PA37442 | 22q12.3 |
GO terms in YWHAH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| MF | ISS | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0017080 | sodium channel regulator activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | ISS | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0035259 | glucocorticoid receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| BP | IDA | GO:0002028 | regulation of sodium ion transport |
| BP | IDA | GO:0006713 | glucocorticoid catabolic process |
| BP | ISS | GO:0006886 | intracellular protein transport |
| BP | HEP | GO:0021762 | substantia nigra development |
| BP | IDA | GO:0042921 | glucocorticoid receptor signaling pathway |
| BP | ISS | GO:0045664 | regulation of neuron differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | ISS | GO:0050774 | negative regulation of dendrite morphogenesis |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IDA | GO:0086010 | membrane depolarization during action potential |
| BP | TAS | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IDA | GO:2000649 | regulation of sodium ion transmembrane transporter activity |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IC | GO:0014704 | intercalated disc |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: YWHAH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in YWHAH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | foxopathway | FoxO family signaling |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| pid | lkb1_pathway | LKB1 signaling events |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111447 | Activation of BAD and translocation to mitochondria |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | mitrpathway | signal dependent regulation of myogenesis by corepressor mitr |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 7 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD48 | Dexamethasone | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in YWHAH
CLASSFICATION
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