YWHAH

Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
OMIM IDMIM:113508
Ensembl IDEnsembl:ENSG00000128245
HGNC IDHGNC:HGNC:12853
PHARMGKB IDPA37442
Map Location22q12.3

Gene Categories:

TRANSPORTERION CHANNEL

GO terms in YWHAH


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003779 actin binding
MF ISS GO:0005159 insulin-like growth factor receptor binding
MF IPI GO:0005515 protein binding
MF IDA GO:0017080 sodium channel regulator activity
MF IPI GO:0019899 enzyme binding
MF ISS GO:0019904 protein domain specific binding
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Gene expression in normal tissue: YWHAH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Chromatin other1PI3K/MTOR signaling1Drug metabolism - cytochrome P4501DNA replication1Neuroactive ligand-receptor interaction1Chromatin histone acetylation1Longevity regulating pathway1ERK MAPK signaling1Biosynthesis of secondary metabolites1

Pathways in YWHAH


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Database
Pathway ID
Pathway Des.
netpath Pathway_Alpha6Beta4Integrin Alpha6Beta4Integrin
netpath Pathway_TNFalpha TNFalpha
pid a6b1_a6b4_integrin_pathway a6b1 and a6b4 Integrin signaling
pid betacatenin_nuc_pathway Regulation of nuclear beta catenin signaling and target gene transcription
pid erbb1_downstream_pathway ErbB1 downstream signaling
pid foxopathway FoxO family signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD451 Serdemetan 2
iGMDRD23 Gossypol 4
iGMDRD64 Parbendazole 2
iGMDRD60 Quinoclamine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YWHAH

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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