ZAP70
Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:176947 Ensembl IDEnsembl:ENSG00000115085 HGNC IDHGNC:HGNC:12858 PHARMGKB IDPA37447 Map Location2q11.2 | |||||
GO terms in ZAP70
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0001784 | phosphotyrosine residue binding |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | NAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
Gene expression in normal tissue: ZAP70
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZAP70
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZAP70
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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