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ZAP70

Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
zeta chain of T cell receptor associated protein kinase 70	MIM:176947	Ensembl:ENSG00000115085	HGNC:HGNC:12858	PA37447	2q11.2

Gene Categories:

KINASE TYROSINE KINASE DRUGGABLE GENOME

GO terms in ZAP70

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IMP	GO:0001784	phosphotyrosine residue binding
MF	IPI	GO:0001784	phosphotyrosine residue binding
MF	IDA	GO:0004713	protein tyrosine kinase activity
MF	NAS	GO:0004713	protein tyrosine kinase activity
MF	TAS	GO:0004713	protein tyrosine kinase activity
MF	TAS	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IPI	GO:0005515	protein binding
MF	NAS	GO:0005524	ATP binding
CC	IEA	GO:0001772	immunological synapse
CC	TAS	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IEA	GO:0005911	cell-cell junction
CC	IDA	GO:0042101	T cell receptor complex
CC	IDA	GO:0045121	membrane raft
BP	TAS	GO:0002250	adaptive immune response
BP	IDA	GO:0006468	protein phosphorylation
BP	NAS	GO:0006468	protein phosphorylation
BP	IDA	GO:0006955	immune response
BP	IDA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IMP	GO:0018108	peptidyl-tyrosine phosphorylation
BP	NAS	GO:0030217	T cell differentiation
BP	NAS	GO:0035556	intracellular signal transduction
BP	TAS	GO:0042110	T cell activation
BP	TAS	GO:0042113	B cell activation
BP	IEA	GO:0043366	beta selection
BP	IDA	GO:0045059	positive thymic T cell selection
BP	IEA	GO:0045060	negative thymic T cell selection
BP	IDA	GO:0045582	positive regulation of T cell differentiation
BP	IEA	GO:0046638	positive regulation of alpha-beta T cell differentiation
BP	IEA	GO:0046641	positive regulation of alpha-beta T cell proliferation
BP	IEA	GO:0050850	positive regulation of calcium-mediated signaling
BP	TAS	GO:0050852	T cell receptor signaling pathway
BP	TAS	GO:0070489	T cell aggregation
BP	TAS	GO:0072678	T cell migration

Gene expression in normal tissue: ZAP70

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZAP70

Database	Pathway ID	Pathway Des.
netpath	Pathway_BCR	BCR
netpath	Pathway_Prolactin	Prolactin
netpath	Pathway_TCR	TCR
pid	cd8tcrpathway	TCR signaling in naïve CD8+ T cells
pid	pi3kcipathway	Class I PI3K signaling events
pid	tcr_pathway	TCR signaling in naïve CD4+ T cells
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04064	NF-kappa B signaling pathway - Homo sapiens (human)
kegg	hsa04650	Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg	hsa04658	Th1 and Th2 cell differentiation - Homo sapiens (human)
kegg	hsa04659	Th17 cell differentiation - Homo sapiens (human)
kegg	hsa04660	T cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa05340	Primary immunodeficiency - Homo sapiens (human)
wikipathways	WP2037	Prolactin Signaling Pathway
wikipathways	WP2583	T-Cell Receptor and Co-stimulatory Signaling
wikipathways	WP2593	JAK-STAT
wikipathways	WP3863	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathways	WP4223	Ras Signaling
wikipathways	WP453	Inflammatory Response Pathway
wikipathways	WP585	Interferon type I signaling pathways
wikipathways	WP69	T-Cell antigen Receptor (TCR) Signaling Pathway
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-202403	TCR signaling
reactome	R-HSA-202430	Translocation of ZAP-70 to Immunological synapse
reactome	R-HSA-202433	Generation of second messenger molecules
biocarta	cskpathway	activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocarta	mef2dpathway	role of mef2d in t-cell apoptosis
biocarta	tcrapathway	lck and fyn tyrosine kinases in initiation of tcr activation
biocarta	tcrpathway	t cell receptor signaling pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD640	CAY10618	1
iGMDRD60	Quinoclamine	2
iGMDRD353	PD0325901	1
iGMDRD887	Compound 23 citrate	2
iGMDRD398	Sepantronium	1
iGMDRD577	BIX01294	2
iGMDRD6	AM-580	3
iGMDRD801	2,4-dideoxy-DC-45-A2	1
iGMDRD121	GMX1778	2
iGMDRD446	LY 2183240	2
iGMDRD341	Triacsin c	4
iGMDRD61	Kinetin riboside	3
iGMDRD237	ABT-751	2
iGMDRD152	179324-69-7	4
iGMDRD314	Tanespimycin	1
iGMDRD427	ABT737	3
iGMDRD781	Sirolimus	3
iGMDRD554	CHEMBL1434137	1
iGMDRD387	CHIR-99021	3
iGMDRD599	Salermide	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZAP70

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DATATYPES

CLASSFICATION

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