ZIC3
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300265 Ensembl IDEnsembl:ENSG00000156925 HGNC IDHGNC:HGNC:12874 PHARMGKB IDPA37463 Map LocationXq26.3 | |||||
GO terms in ZIC3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0001947 | heart looping |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0007368 | determination of left/right symmetry |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030324 | lung development |
Gene expression in normal tissue: ZIC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZIC3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3333 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZIC3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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