ZIC3
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Zic family member 3 | MIM:300265 | Ensembl:ENSG00000156925 | HGNC:HGNC:12874 | PA37463 | Xq26.3 |
GO terms in ZIC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0001947 | heart looping |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0007368 | determination of left/right symmetry |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030324 | lung development |
| BP | TAS | GO:0035019 | somatic stem cell population maintenance |
| BP | IMP | GO:0035469 | determination of pancreatic left/right asymmetry |
| BP | IEA | GO:0035545 | determination of left/right asymmetry in nervous system |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0071907 | determination of digestive tract left/right asymmetry |
| BP | IMP | GO:0071910 | determination of liver left/right asymmetry |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ZIC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZIC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3333 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZIC3
CLASSFICATION
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