THTPA


Summary: This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:611612
PHARMGKB IDPA38774
Map Location14q11.2

GO terms in THTPA


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005829 cytosol
BP NAS GO:0006091 generation of precursor metabolites and energy
BP TAS GO:0006772 thiamine metabolic process
BP IDA GO:0016311 dephosphorylation
BP ISS GO:0042357 thiamine diphosphate metabolic process
BP TAS GO:0042723 thiamine-containing compound metabolic process
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Gene expression in normal tissue: THTPA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in THTPA


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-196819 Vitamin B1 (thiamin) metabolism
reactome R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
reactome R-HSA-196854 Metabolism of vitamins and cofactors
kegg hsa00730 Thiamine metabolism - Homo sapiens (human)
smpdb SMP00076 Thiamine Metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THTPA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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