B3GNT4

Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
OMIM IDMIM:605864
Ensembl IDEnsembl:ENSG00000176383
HGNC IDHGNC:HGNC:15683
PHARMGKB IDPA25220
Map Location12q24.31

GO terms in B3GNT4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0008375 acetylglucosaminyltransferase activity
MF IBA GO:0008376 acetylgalactosaminyltransferase activity
MF TAS GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
MF IBA GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
MF IDA GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
MF TAS GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
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Gene expression in normal tissue: B3GNT4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in B3GNT4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1630316 Glycosaminoglycan metabolism
reactome R-HSA-1638074 Keratan sulfate/keratin metabolism
reactome R-HSA-2022854 Keratan sulfate biosynthesis
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-5173105 O-linked glycosylation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in B3GNT4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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