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FYCO1

Summary: This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameFYVE and coiled-coil domain containing 1 OMIM IDMIM:607182 Ensembl IDEnsembl:ENSG00000163820 HGNC IDHGNC:HGNC:14673 PHARMGKB IDPA28453 Map Location3p21.31

GO terms in FYCO1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0046872	metal ion binding
BP	IBA	GO:0072383	plus-end-directed vesicle transport along microtubule
BP	IMP	GO:0072383	plus-end-directed vesicle transport along microtubule
BP	IBA	GO:1901098	positive regulation of autophagosome maturation
BP	IMP	GO:1901098	positive regulation of autophagosome maturation

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Gene expression in normal tissue: FYCO1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FYCO1

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FYCO1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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