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FYCO1

Summary: This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
FYVE and coiled-coil domain containing 1	MIM:607182	Ensembl:ENSG00000163820	HGNC:HGNC:14673	PA28453	3p21.31

GO terms in FYCO1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0046872	metal ion binding
BP	IBA	GO:0072383	plus-end-directed vesicle transport along microtubule
BP	IMP	GO:0072383	plus-end-directed vesicle transport along microtubule
BP	IBA	GO:1901098	positive regulation of autophagosome maturation
BP	IMP	GO:1901098	positive regulation of autophagosome maturation
CC	IBA	GO:0005764	lysosome
CC	IDA	GO:0005764	lysosome
CC	IBA	GO:0005770	late endosome
CC	IDA	GO:0005770	late endosome
CC	IBA	GO:0005776	autophagosome
CC	IDA	GO:0005776	autophagosome
CC	IDA	GO:0005794	Golgi apparatus
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0043231	intracellular membrane-bounded organelle

Gene expression in normal tissue: FYCO1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FYCO1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FYCO1

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CLASSFICATION

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