Summary: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013].

baculoviral IAP repeat containing 7MIM:605737Ensembl:ENSG00000101197HGNC:HGNC:13702PA2536420q13.33

GO terms in BIRC7

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004869cysteine-type endopeptidase inhibitor activity
MFIPIGO:0005515protein binding
MFNASGO:0019899enzyme binding
MFIBAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
MFIEAGO:0046872metal ion binding
MFIBAGO:0061630ubiquitin protein ligase activity
BPIEAGO:0006915apoptotic process
BPNASGO:0007257activation of JUN kinase activity
BPIDAGO:0016567protein ubiquitination
BPIDAGO:0042127regulation of cell proliferation
BPIMPGO:0043066negative regulation of apoptotic process
BPNASGO:0043066negative regulation of apoptotic process
BPIDAGO:0070247regulation of natural killer cell apoptotic process
BPIBAGO:0090307mitotic spindle assembly
BPIBAGO:1990001inhibition of cysteine-type endopeptidase activity involved in apoptotic process
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005815microtubule organizing center

Gene expression in normal tissue: BIRC7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BIRC7

DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BIRC7