RNASEH2B
Summary: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610326 Ensembl IDEnsembl:ENSG00000136104 HGNC IDHGNC:HGNC:25671 PHARMGKB IDPA162401418 Map Location13q14.3 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in RNASEH2B
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IDA | GO:0006401 | RNA catabolic process |
| BP | IEA | GO:0009259 | ribonucleotide metabolic process |
| BP | IEA | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
Gene expression in normal tissue: RNASEH2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASEH2B
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASEH2B
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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