RIN3
Summary: Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Ras and Rab interactor 3 | MIM:610223 | Ensembl:ENSG00000100599 | HGNC:HGNC:18751 | PA38673 | 14q32.12 |
GO terms in RIN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0017112 | Rab guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0017112 | Rab guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0017137 | Rab GTPase binding |
| CC | IDA | GO:0005769 | early endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| BP | NAS | GO:0006897 | endocytosis |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
Gene expression in normal tissue: RIN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIN3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs |
| reactome | R-HSA-9007101 | Rab regulation of trafficking |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIN3
CLASSFICATION
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