TUSC3
Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tumor suppressor candidate 3 | MIM:601385 | Ensembl:ENSG00000104723 | HGNC:HGNC:30242 | PA128394537 | 8p22 |
GO terms in TUSC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0008250 | oligosaccharyltransferase complex |
| CC | IDA | GO:0008250 | oligosaccharyltransferase complex |
| BP | NAS | GO:0006487 | protein N-linked glycosylation |
| BP | IMP | GO:0015693 | magnesium ion transport |
| BP | IBA | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | IMP | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | ISS | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | IMP | GO:0050890 | cognition |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IEA | GO:1903830 | magnesium ion transmembrane transport |
| MF | IBA | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | ISS | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | IMP | GO:0015095 | magnesium ion transmembrane transporter activity |
| MF | TAS | GO:0015095 | magnesium ion transmembrane transporter activity |
Gene expression in normal tissue: TUSC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TUSC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5223345 | Miscellaneous transport and binding events |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa00510 | N-Glycan biosynthesis - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TUSC3
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.