TUSC3


Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tumor suppressor candidate 3MIM:601385Ensembl:ENSG00000104723HGNC:HGNC:30242PA1283945378p22

GO terms in TUSC3


Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0005739mitochondrion
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIBAGO:0008250oligosaccharyltransferase complex
CCIDAGO:0008250oligosaccharyltransferase complex
BPNASGO:0006487protein N-linked glycosylation
BPIMPGO:0015693magnesium ion transport
BPIBAGO:0018279protein N-linked glycosylation via asparagine
BPIMPGO:0018279protein N-linked glycosylation via asparagine
BPISSGO:0018279protein N-linked glycosylation via asparagine
BPIMPGO:0050890cognition
BPTASGO:0055085transmembrane transport
BPIEAGO:1903830magnesium ion transmembrane transport
MFIBAGO:0004579dolichyl-diphosphooligosaccharide-protein glycotransferase activity
MFISSGO:0004579dolichyl-diphosphooligosaccharide-protein glycotransferase activity
MFIMPGO:0015095magnesium ion transmembrane transporter activity
MFTASGO:0015095magnesium ion transmembrane transporter activity

Gene expression in normal tissue: TUSC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TUSC3


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5223345Miscellaneous transport and binding events
reactomeR-HSA-597592Post-translational protein modification
kegghsa00510N-Glycan biosynthesis - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
wikipathwaysWP4239EMT transition in Colorectal Cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TUSC3

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