PLPPR3
Summary: The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipid phosphatase related 3 | MIM:610391 | Ensembl:ENSG00000129951 | HGNC:HGNC:23497 | 19p13.3 |
GO terms in PLPPR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0008195 | phosphatidate phosphatase activity |
| MF | IBA | GO:0016791 | phosphatase activity |
| MF | IBA | GO:0042577 | lipid phosphatase activity |
| BP | IBA | GO:0006644 | phospholipid metabolic process |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IBA | GO:0046839 | phospholipid dephosphorylation |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: PLPPR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLPPR3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-419408 | Lysosphingolipid and LPA receptors |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLPPR3
CLASSFICATION
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