ATAT1
Summary: This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
alpha tubulin acetyltransferase 1 | MIM:615556 | Ensembl:ENSG00000137343 | HGNC:HGNC:21186 | PA134948212 | 6p21.33 |
GO terms in ATAT1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor |
MF | TAS | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor |
MF | IBA | GO:0019799 | tubulin N-acetyltransferase activity |
MF | IDA | GO:0019799 | tubulin N-acetyltransferase activity |
MF | IMP | GO:0019799 | tubulin N-acetyltransferase activity |
MF | IDA | GO:0050662 | coenzyme binding |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0005874 | microtubule |
CC | IEA | GO:0005905 | clathrin-coated pit |
CC | IEA | GO:0005925 | focal adhesion |
CC | IEA | GO:0030424 | axon |
CC | IDA | GO:0072686 | mitotic spindle |
CC | IEA | GO:0097427 | microtubule bundle |
BP | IEA | GO:0007283 | spermatogenesis |
BP | IEA | GO:0021542 | dentate gyrus development |
BP | IEA | GO:0045598 | regulation of fat cell differentiation |
BP | TAS | GO:0060271 | cilium assembly |
BP | IBA | GO:0071929 | alpha-tubulin acetylation |
BP | IDA | GO:0071929 | alpha-tubulin acetylation |
BP | IEA | GO:1900227 | positive regulation of NLRP3 inflammasome complex assembly |
Gene expression in normal tissue: ATAT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATAT1
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
reactome | R-HSA-5617833 | Cilium Assembly |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in ATAT1