SEMA6D
Summary: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| semaphorin 6D | MIM:609295 | Ensembl:ENSG00000137872 | HGNC:HGNC:16770 | PA134951035 | 15q21.1 |
GO terms in SEMA6D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | IBA | GO:0001755 | neural crest cell migration |
| BP | IEA | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | IEA | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | IEA | GO:0021591 | ventricular system development |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0048843 | negative regulation of axon extension involved in axon guidance |
| BP | IBA | GO:0050919 | negative chemotaxis |
| BP | IBA | GO:0071526 | semaphorin-plexin signaling pathway |
| MF | IBA | GO:0030215 | semaphorin receptor binding |
| MF | IEA | GO:0030215 | semaphorin receptor binding |
| MF | IBA | GO:0038191 | neuropilin binding |
| MF | IBA | GO:0045499 | chemorepellent activity |
Gene expression in normal tissue: SEMA6D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEMA6D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-416700 | Other semaphorin interactions |
| reactome | R-HSA-422475 | Axon guidance |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEMA6D
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