SEMA6D


Summary: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:609295
PHARMGKB IDPA134951035
Map Location15q21.1

GO terms in SEMA6D


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005615 extracellular space
CC IDA GO:0005794 Golgi apparatus
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
BP IBA GO:0001755 neural crest cell migration
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Gene expression in normal tissue: SEMA6D

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in SEMA6D


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-373755 Semaphorin interactions
reactome R-HSA-416700 Other semaphorin interactions
reactome R-HSA-422475 Axon guidance
kegg hsa04360 Axon guidance - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEMA6D

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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