CXXC4


Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:611645
PHARMGKB IDPA134992016
Map Location4q24

GO terms in CXXC4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003677 DNA binding
MF IEA GO:0008270 zinc ion binding
MF IPI GO:0030165 PDZ domain binding
BP ISS GO:0007352 zygotic specification of dorsal/ventral axis
BP IEA GO:0016055 Wnt signaling pathway
BP IDA GO:0030178 negative regulation of Wnt signaling pathway
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Gene expression in normal tissue: CXXC4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in CXXC4


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Database
Pathway ID
Pathway Des.
kegg hsa04310 Wnt signaling pathway - Homo sapiens (human)
wikipathways WP428 Wnt Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXXC4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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