MFAP5
Summary: This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601103 Ensembl IDEnsembl:ENSG00000197614 HGNC IDHGNC:HGNC:29673 PHARMGKB IDPA134915148 Map Location12p13.31 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in MFAP5
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005201 | extracellular matrix structural constituent |
| CC | ISS | GO:0001527 | microfibril |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | ISS | GO:0060216 | definitive hemopoiesis |
Gene expression in normal tissue: MFAP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MFAP5
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | notch_pathway | Notch signaling pathway |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-1566948 | Elastic fibre formation |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MFAP5
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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