AP3B2
Summary: Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adaptor related protein complex 3 subunit beta 2 | MIM:602166 | Ensembl:ENSG00000103723 | HGNC:HGNC:567 | PA24858 | 15q25.2 |
Gene Categories:
TRANSPORTERGO terms in AP3B2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006886 | intracellular protein transport |
| BP | TAS | GO:0006892 | post-Golgi vesicle-mediated transport |
| BP | ISS | GO:0008089 | anterograde axonal transport |
| BP | ISS | GO:0048490 | anterograde synaptic vesicle transport |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0030123 | AP-3 adaptor complex |
| CC | TAS | GO:0030137 | COPI-coated vesicle |
| CC | IEA | GO:0030665 | clathrin-coated vesicle membrane |
| CC | IEA | GO:1904115 | axon cytoplasm |
| MF | TAS | GO:0005215 | transporter activity |
Gene expression in normal tissue: AP3B2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AP3B2
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