ST8SIA2

Summary: The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
OMIM IDMIM:602546
Ensembl IDEnsembl:ENSG00000140557
HGNC IDHGNC:HGNC:10870
PHARMGKB IDPA35771
Map Location15q26.1

GO terms in ST8SIA2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0001574 ganglioside biosynthetic process
BP TAS GO:0005975 carbohydrate metabolic process
BP TAS GO:0006464 cellular protein modification process
BP IDA GO:0006486 protein glycosylation
BP IEA GO:0006486 protein glycosylation
BP IDA GO:0006491 N-glycan processing
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Gene expression in normal tissue: ST8SIA2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

Protein stability and degradation1ERK MAPK signaling1

Pathways in ST8SIA2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-375165 NCAM signaling for neurite out-growth
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-4085001 Sialic acid metabolism
reactome R-HSA-419037 NCAM1 interactions
reactome R-HSA-422475 Axon guidance
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ST8SIA2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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