SLC38A1
Summary: Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 38 member 1 | MIM:608490 | Ensembl:ENSG00000111371 | HGNC:HGNC:13447 | PA37772 | 12q13.11 |
Gene Categories:
TRANSPORTERGO terms in SLC38A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0001504 | neurotransmitter uptake |
| BP | IBA | GO:0003333 | amino acid transmembrane transport |
| BP | IEA | GO:0006814 | sodium ion transport |
| BP | TAS | GO:0006865 | amino acid transport |
| BP | NAS | GO:0015804 | neutral amino acid transport |
| BP | IEA | GO:1902475 | L-alpha-amino acid transmembrane transport |
| MF | NAS | GO:0005283 | amino acid:sodium symporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015171 | amino acid transmembrane transporter activity |
| MF | TAS | GO:0015171 | amino acid transmembrane transporter activity |
| MF | NAS | GO:0015175 | neutral amino acid transmembrane transporter activity |
| MF | TAS | GO:0015179 | L-amino acid transmembrane transporter activity |
Gene expression in normal tissue: SLC38A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC38A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism |
| reactome | R-HSA-352230 | Amino acid transport across the plasma membrane |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC38A1
CLASSFICATION
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