SLC38A1

Summary: Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesolute carrier family 38 member 1
OMIM IDMIM:608490
Ensembl IDEnsembl:ENSG00000111371
HGNC IDHGNC:HGNC:13447
PHARMGKB IDPA37772
Map Location12q13.11

Gene Categories:

TRANSPORTER

GO terms in SLC38A1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC NAS GO:0016021 integral component of membrane
CC HDA GO:0070062 extracellular exosome
BP TAS GO:0001504 neurotransmitter uptake
BP IBA GO:0003333 amino acid transmembrane transport
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Gene expression in normal tissue: SLC38A1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in SLC38A1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112313 Neurotransmitter uptake and metabolism In glial cells
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
reactome R-HSA-352230 Amino acid transport across the plasma membrane
reactome R-HSA-382551 Transport of small molecules
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC38A1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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