VMP1
Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:611753 Ensembl IDEnsembl:ENSG00000062716 HGNC IDHGNC:HGNC:29559 PHARMGKB IDPA142670765 Map Location17q23.1 |
GO terms in VMP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0006887 | exocytosis |
BP | IEA | GO:0006914 | autophagy |
BP | IBA | GO:0007029 | endoplasmic reticulum organization |
BP | IBA | GO:0007030 | Golgi organization |
BP | IEA | GO:0007566 | embryo implantation |
BP | IBA | GO:0016236 | macroautophagy |
Gene expression in normal tissue: VMP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VMP1
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in VMP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |