VMP1
Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vacuole membrane protein 1 | MIM:611753 | Ensembl:ENSG00000062716 | HGNC:HGNC:29559 | PA142670765 | 17q23.1 |
GO terms in VMP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006887 | exocytosis |
| BP | IEA | GO:0006914 | autophagy |
| BP | IBA | GO:0007029 | endoplasmic reticulum organization |
| BP | IBA | GO:0007030 | Golgi organization |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | IBA | GO:0016236 | macroautophagy |
| BP | IMP | GO:0034329 | cell junction assembly |
| BP | IMP | GO:0098609 | cell-cell adhesion |
| CC | IBA | GO:0000407 | phagophore assembly site |
| CC | ISS | GO:0000421 | autophagosome membrane |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: VMP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VMP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VMP1
CLASSFICATION
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