VMP1


Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in VMP1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006887 exocytosis
BP IEA GO:0006914 autophagy
BP IBA GO:0007029 endoplasmic reticulum organization
BP IBA GO:0007030 Golgi organization
BP IEA GO:0007566 embryo implantation
BP IBA GO:0016236 macroautophagy
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Gene expression in normal tissue: VMP1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Pathways in VMP1


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Database
Pathway ID
Pathway Des.
kegg hsa04140 Autophagy - animal - Homo sapiens (human)
wikipathways WP2509 Nanoparticle triggered autophagic cell death
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VMP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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