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DOCK8

Summary: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namededicator of cytokinesis 8 OMIM IDMIM:611432 Ensembl IDEnsembl:ENSG00000107099 HGNC IDHGNC:HGNC:19191 PHARMGKB IDPA134918866 Map Location9p24.3

GO terms in DOCK8

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0031256	leading edge membrane
CC	IEA	GO:0031258	lamellipodium membrane
BP	IEA	GO:0001771	immunological synapse formation

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Gene expression in normal tissue: DOCK8

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DOCK8

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-983231	Factors involved in megakaryocyte development and platelet production

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DOCK8

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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