SEH1L

Summary: The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSEH1 like nucleoporin
OMIM IDMIM:609263
Ensembl IDEnsembl:ENSG00000085415
HGNC IDHGNC:HGNC:30379
PHARMGKB IDPA134912135
Map Location18p11.21

GO terms in SEH1L


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005198 structural molecule activity
MF IEA GO:0005198 structural molecule activity
MF IPI GO:0005515 protein binding
MF IBA GO:0042802 identical protein binding
CC IBA GO:0000776 kinetochore
CC IDA GO:0000776 kinetochore
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Gene expression in normal tissue: SEH1L

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in SEH1L


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Database
Pathway ID
Pathway Des.
kegg hsa03013 RNA transport - Homo sapiens (human)
kegg hsa04150 mTOR signaling pathway - Homo sapiens (human)
reactome R-HSA-1169408 ISG15 antiviral mechanism
reactome R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-141424 Amplification of signal from the kinetochores
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEH1L

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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