CAPN2
Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calpain 2 | MIM:114230 | Ensembl:ENSG00000162909 | HGNC:HGNC:1479 | PA26060 | 1q41 |
GO terms in CAPN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001824 | blastocyst development |
| BP | IBA | GO:0006508 | proteolysis |
| BP | ISS | GO:0006508 | proteolysis |
| BP | IEA | GO:0007520 | myoblast fusion |
| BP | IEA | GO:0016540 | protein autoprocessing |
| BP | TAS | GO:0051493 | regulation of cytoskeleton organization |
| BP | IDA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | ISS | GO:0071230 | cellular response to amino acid stimulus |
| CC | IEA | GO:0000785 | chromatin |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005764 | lysosome |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0030425 | dendrite |
| CC | TAS | GO:0030864 | cortical actin cytoskeleton |
| CC | IDA | GO:0031143 | pseudopodium |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IDA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097038 | perinuclear endoplasmic reticulum |
| MF | IBA | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| MF | IDA | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| MF | ISS | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008092 | cytoskeletal protein binding |
| MF | TAS | GO:0008234 | cysteine-type peptidase activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: CAPN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAPN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAPN2
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