ACOX2
Summary: The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601641 Ensembl IDEnsembl:ENSG00000168306 HGNC IDHGNC:HGNC:120 PHARMGKB IDPA24444 Map Location3p14.3 | |||||
GO terms in ACOX2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003995 | acyl-CoA dehydrogenase activity |
| MF | IBA | GO:0003997 | acyl-CoA oxidase activity |
| MF | TAS | GO:0003997 | acyl-CoA oxidase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IBA | GO:0005504 | fatty acid binding |
| MF | TAS | GO:0016402 | pristanoyl-CoA oxidase activity |
Gene expression in normal tissue: ACOX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACOX2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP3942 | PPAR signaling pathway |
| smpdb | SMP00035 | Bile Acid Biosynthesis |
| smpdb | SMP00314 | Congenital Bile Acid Synthesis Defect Type II |
| smpdb | SMP00315 | Cerebrotendinous Xanthomatosis (CTX) |
| smpdb | SMP00316 | Zellweger Syndrome |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACOX2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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