CDC45
Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 45 | MIM:603465 | Ensembl:ENSG00000093009 | HGNC:HGNC:1739 | PA371 | 22q11.21 |
GO terms in CDC45
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000076 | DNA replication checkpoint |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0000727 | double-strand break repair via break-induced replication |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication |
| BP | IBA | GO:0006270 | DNA replication initiation |
| BP | IBA | GO:0031938 | regulation of chromatin silencing at telomere |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | IBA | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| BP | IBA | GO:1902977 | mitotic DNA replication preinitiation complex assembly |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005656 | nuclear pre-replicative complex |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0031261 | DNA replication preinitiation complex |
| CC | IBA | GO:0031298 | replication fork protection complex |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003688 | DNA replication origin binding |
| MF | IBA | GO:0003697 | single-stranded DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0043138 | 3'-5' DNA helicase activity |
Gene expression in normal tissue: CDC45
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC45
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-176974 | Unwinding of DNA |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP466 | DNA Replication |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC45
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