Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

cell division cycle 45MIM:603465Ensembl:ENSG00000093009HGNC:HGNC:1739PA37122q11.21

GO terms in CDC45

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000076DNA replication checkpoint
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIBAGO:0000727double-strand break repair via break-induced replication
BPTASGO:0006260DNA replication
BPIBAGO:0006267pre-replicative complex assembly involved in nuclear cell cycle DNA replication
BPIBAGO:0006270DNA replication initiation
BPIBAGO:0031938regulation of chromatin silencing at telomere
BPIEAGO:0032508DNA duplex unwinding
BPIBAGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPIBAGO:1902977mitotic DNA replication preinitiation complex assembly
CCIBAGO:0005656nuclear pre-replicative complex
CCIBAGO:0031261DNA replication preinitiation complex
CCIBAGO:0031298replication fork protection complex
MFIBAGO:0003682chromatin binding
MFIBAGO:0003688DNA replication origin binding
MFIBAGO:0003697single-stranded DNA binding
MFIPIGO:0005515protein binding
MFIBAGO:00431383'-5' DNA helicase activity

Gene expression in normal tissue: CDC45

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC45

DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-176187Activation of ATR in response to replication stress
reactomeR-HSA-176974Unwinding of DNA
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
kegghsa04110Cell cycle - Homo sapiens (human)
wikipathwaysWP179Cell Cycle
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP466DNA Replication

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC45