CHST9
Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carbohydrate sulfotransferase 9 | MIM:610191 | Ensembl:ENSG00000154080 | HGNC:HGNC:19898 | PA134888782 | 18q11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CHST9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005576 | extracellular region |
| CC | NAS | GO:0016021 | integral component of membrane |
| BP | IDA | GO:0006790 | sulfur compound metabolic process |
| BP | IEA | GO:0016051 | carbohydrate biosynthetic process |
| BP | ISS | GO:0030166 | proteoglycan biosynthetic process |
| BP | NAS | GO:0030203 | glycosaminoglycan metabolic process |
| BP | TAS | GO:0030206 | chondroitin sulfate biosynthetic process |
| BP | ISS | GO:0042446 | hormone biosynthetic process |
| MF | IDA | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity |
| MF | ISS | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity |
| MF | TAS | GO:0047756 | chondroitin 4-sulfotransferase activity |
Gene expression in normal tissue: CHST9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHST9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
| reactome | R-HSA-2022870 | Chondroitin sulfate biosynthesis |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHST9
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