CHST9
Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610191 Ensembl IDEnsembl:ENSG00000154080 HGNC IDHGNC:HGNC:19898 PHARMGKB IDPA134888782 Map Location18q11.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CHST9
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005576 | extracellular region |
| CC | NAS | GO:0016021 | integral component of membrane |
| BP | IDA | GO:0006790 | sulfur compound metabolic process |
| BP | IEA | GO:0016051 | carbohydrate biosynthetic process |
| BP | ISS | GO:0030166 | proteoglycan biosynthetic process |
Gene expression in normal tissue: CHST9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHST9
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
| reactome | R-HSA-2022870 | Chondroitin sulfate biosynthesis |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHST9
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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