MIXL1
Summary: Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Mix paired-like homeobox | MIM:609852 | Ensembl:ENSG00000185155 | HGNC:HGNC:13363 | PA134976348 | 1q42.12 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in MIXL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | ISS | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | ISS | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| BP | ISS | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | ISS | GO:0007369 | gastrulation |
| BP | ISS | GO:0007492 | endoderm development |
| BP | ISS | GO:0007507 | heart development |
| BP | ISS | GO:0035987 | endodermal cell differentiation |
| BP | IEA | GO:0042074 | cell migration involved in gastrulation |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0048565 | digestive tract development |
| BP | ISS | GO:1901533 | negative regulation of hematopoietic progenitor cell differentiation |
| BP | ISS | GO:2000382 | positive regulation of mesoderm development |
| CC | ISS | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
Gene expression in normal tissue: MIXL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIXL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIXL1
CLASSFICATION
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