PRAM1

Summary: The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NamePML-RARA regulated adaptor molecule 1
OMIM IDMIM:606466
Ensembl IDEnsembl:ENSG00000133246
HGNC IDHGNC:HGNC:30091
PHARMGKB IDPA142671137
Map Location19p13.2

GO terms in PRAM1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0007165 signal transduction
CC IBA GO:0005886 plasma membrane
CC IDA GO:0032991 protein-containing complex
MF IPI GO:0005515 protein binding
MF IEA GO:0008289 lipid binding
MF IPI GO:0019901 protein kinase binding
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Gene expression in normal tissue: PRAM1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Pathways in PRAM1


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Database
Pathway ID
Pathway Des.
biocarta pmlpathway regulation of transcriptional activity by pml
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRAM1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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