PRAM1


Summary: The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PML-RARA regulated adaptor molecule 1MIM:606466Ensembl:ENSG00000133246HGNC:HGNC:30091PA14267113719p13.2

GO terms in PRAM1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007165signal transduction
CCIBAGO:0005886plasma membrane
CCIDAGO:0032991protein-containing complex
MFIPIGO:0005515protein binding
MFIEAGO:0008289lipid binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: PRAM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRAM1


DatabasePathway IDPathway Des.
biocartapmlpathwayregulation of transcriptional activity by pml

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRAM1

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