ZNRF3


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
zinc and ring finger 3MIM:612062Ensembl:ENSG00000183579HGNC:HGNC:18126PA13498389722q12.1

GO terms in ZNRF3


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIBAGO:0005109frizzled binding
MFIPIGO:0005109frizzled binding
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0061630ubiquitin protein ligase activity
MFTASGO:0061630ubiquitin protein ligase activity
BPIBAGO:0006511ubiquitin-dependent protein catabolic process
BPIMPGO:0006511ubiquitin-dependent protein catabolic process
BPIDAGO:0016567protein ubiquitination
BPIEAGO:0016567protein ubiquitination
BPIBAGO:0038018Wnt receptor catabolic process
BPIMPGO:0038018Wnt receptor catabolic process
BPTASGO:0038018Wnt receptor catabolic process
BPIEAGO:0060070canonical Wnt signaling pathway
BPIEAGO:0060071Wnt signaling pathway, planar cell polarity pathway
BPISSGO:0072089stem cell proliferation
BPIBAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPIMPGO:2000051negative regulation of non-canonical Wnt signaling pathway
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane

Gene expression in normal tissue: ZNRF3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ZNRF3


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-4641263Regulation of FZD by ubiquitination

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD991Porcupine inhibitor2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZNRF3

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