ZNRF3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc and ring finger 3 | MIM:612062 | Ensembl:ENSG00000183579 | HGNC:HGNC:18126 | PA134983897 | 22q12.1 |
GO terms in ZNRF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IBA | GO:0005109 | frizzled binding |
| MF | IPI | GO:0005109 | frizzled binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | TAS | GO:0061630 | ubiquitin protein ligase activity |
| BP | IBA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0038018 | Wnt receptor catabolic process |
| BP | IMP | GO:0038018 | Wnt receptor catabolic process |
| BP | TAS | GO:0038018 | Wnt receptor catabolic process |
| BP | IEA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IEA | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | ISS | GO:0072089 | stem cell proliferation |
| BP | IBA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: ZNRF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZNRF3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-4641263 | Regulation of FZD by ubiquitination |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZNRF3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.