SLX4
Summary: This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:613278 Ensembl IDEnsembl:ENSG00000188827 HGNC IDHGNC:HGNC:23845 PHARMGKB IDPA134983583 Map Location16p13.3 | |||||
Gene Categories:
DNA REPAIRGO terms in SLX4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000706 | meiotic DNA double-strand break processing |
| BP | IBA | GO:0000712 | resolution of meiotic recombination intermediates |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IMP | GO:0006281 | DNA repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
Gene expression in normal tissue: SLX4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLX4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLX4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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