SLX4
Summary: This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SLX4 structure-specific endonuclease subunit | MIM:613278 | Ensembl:ENSG00000188827 | HGNC:HGNC:23845 | PA134983583 | 16p13.3 |
Gene Categories:
DNA REPAIRGO terms in SLX4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000706 | meiotic DNA double-strand break processing |
| BP | IBA | GO:0000712 | resolution of meiotic recombination intermediates |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IMP | GO:0006281 | DNA repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
| BP | IMP | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing |
| BP | IBA | GO:0036297 | interstrand cross-link repair |
| BP | TAS | GO:0036297 | interstrand cross-link repair |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
| BP | IMP | GO:0061820 | telomeric D-loop disassembly |
| BP | IMP | GO:0072429 | response to intra-S DNA damage checkpoint signaling |
| BP | IMP | GO:0090656 | t-circle formation |
| BP | ISS | GO:0090656 | t-circle formation |
| BP | IMP | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| BP | ISS | GO:1904431 | positive regulation of t-circle formation |
| CC | IDA | GO:0000781 | chromosome, telomeric region |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0030054 | cell junction |
| CC | IBA | GO:0033557 | Slx1-Slx4 complex |
| CC | IDA | GO:0033557 | Slx1-Slx4 complex |
| CC | TAS | GO:0033557 | Slx1-Slx4 complex |
| CC | IDA | GO:0048476 | Holliday junction resolvase complex |
| CC | IDA | GO:0070522 | ERCC4-ERCC1 complex |
| MF | TAS | GO:0004520 | endodeoxyribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008047 | enzyme activator activity |
| MF | IBA | GO:0008821 | crossover junction endodeoxyribonuclease activity |
| MF | IDA | GO:0008821 | crossover junction endodeoxyribonuclease activity |
| MF | IBA | GO:0017108 | 5'-flap endonuclease activity |
| MF | IDA | GO:0017108 | 5'-flap endonuclease activity |
| MF | IBA | GO:0048257 | 3'-flap endonuclease activity |
| MF | IDA | GO:0048257 | 3'-flap endonuclease activity |
Gene expression in normal tissue: SLX4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLX4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-6783310 | Fanconi Anemia Pathway |
| reactome | R-HSA-73894 | DNA Repair |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLX4
CLASSFICATION
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