CARD6
Summary: This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase recruitment domain family member 6 | MIM:609986 | Ensembl:ENSG00000132357 | HGNC:HGNC:16394 | PA26076 | 5p13.1 |
GO terms in CARD6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0042981 | regulation of apoptotic process |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CARD6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARD6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARD6
CLASSFICATION
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