GTPBP3


Summary: This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
GTP binding protein 3, mitochondrialMIM:608536Ensembl:ENSG00000130299HGNC:HGNC:14880PA13488320519p13.11

GO terms in GTPBP3


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0002098tRNA wobble uridine modification
BPIEAGO:0006400tRNA modification
BPIBAGO:0030488tRNA methylation
BPIBAGO:0048568embryonic organ development
CCIBAGO:0005737cytoplasm
CCIBAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
MFIEAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding

Gene expression in normal tissue: GTPBP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GTPBP3


DatabasePathway IDPathway Des.
reactomeR-HSA-6787450tRNA modification in the mitochondrion
reactomeR-HSA-72306tRNA processing
reactomeR-HSA-8953854Metabolism of RNA
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GTPBP3

​​​​