USP30
Summary: USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin specific peptidase 30 | MIM:612492 | Ensembl:ENSG00000135093 | HGNC:HGNC:20065 | PA134971149 | 12q24.11 |
GO terms in USP30
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IDA | GO:0000422 | autophagy of mitochondrion |
| BP | IMP | GO:0000422 | autophagy of mitochondrion |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0008053 | mitochondrial fusion |
| BP | IDA | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0035871 | protein K11-linked deubiquitination |
| BP | IDA | GO:0044313 | protein K6-linked deubiquitination |
| BP | IEA | GO:1901525 | negative regulation of mitophagy |
| MF | IMP | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IDA | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
Gene expression in normal tissue: USP30
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in USP30
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in USP30
CLASSFICATION
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