GPAT3
Summary: This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glycerol-3-phosphate acyltransferase 3 | MIM:610958 | Ensembl:ENSG00000138678 | HGNC:HGNC:28157 | PA162375888 | 4q21.23 |
GO terms in GPAT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006654 | phosphatidic acid biosynthetic process |
| BP | IEA | GO:0016024 | CDP-diacylglycerol biosynthetic process |
| BP | IDA | GO:0019432 | triglyceride biosynthetic process |
| BP | IEA | GO:0019432 | triglyceride biosynthetic process |
| BP | IDA | GO:0032006 | regulation of TOR signaling |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | TAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IDA | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity |
| MF | IEA | GO:0102420 | sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity |
Gene expression in normal tissue: GPAT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPAT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-5667 | CDP-diacylglycerol biosynthesis |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| wikipathways | WP2456 | HIF1A and PPARG regulation of glycolysis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483166 | Synthesis of PA |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPAT3
CLASSFICATION
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