HAVCR2
Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hepatitis A virus cellular receptor 2 | MIM:606652 | Ensembl:ENSG00000135077 | HGNC:HGNC:18437 | PA134883425 | 5q33.3 |
Gene Categories:
CELL SURFACEGO terms in HAVCR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IEA | GO:0001772 | immunological synapse |
| CC | IEA | GO:0005769 | early endosome |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0016592 | mediator complex |
| CC | IEA | GO:0030054 | cell junction |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0002281 | macrophage activation involved in immune response |
| BP | IMP | GO:0002519 | natural killer cell tolerance induction |
| BP | IEA | GO:0002652 | regulation of tolerance induction dependent upon immune response |
| BP | IEA | GO:0002826 | negative regulation of T-helper 1 type immune response |
| BP | IEA | GO:0002859 | negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0030886 | negative regulation of myeloid dendritic cell activation |
| BP | IMP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0032687 | negative regulation of interferon-alpha production |
| BP | IDA | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IDA | GO:0032703 | negative regulation of interleukin-2 production |
| BP | IDA | GO:0032712 | negative regulation of interleukin-3 production |
| BP | IEA | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IMP | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IEA | GO:0032722 | positive regulation of chemokine production |
| BP | IEA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IEA | GO:0032732 | positive regulation of interleukin-1 production |
| BP | IMP | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IEA | GO:0032815 | negative regulation of natural killer cell activation |
| BP | IEA | GO:0034138 | toll-like receptor 3 signaling pathway |
| BP | IEA | GO:0034154 | toll-like receptor 7 signaling pathway |
| BP | IEA | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | IEA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IEA | GO:0042130 | negative regulation of T cell proliferation |
| BP | IEA | GO:0043032 | positive regulation of macrophage activation |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IEA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IDA | GO:0060135 | maternal process involved in female pregnancy |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071656 | negative regulation of granulocyte colony-stimulating factor production |
| BP | IEA | GO:1900425 | negative regulation of defense response to bacterium |
| BP | IEA | GO:1900426 | positive regulation of defense response to bacterium |
| BP | IEA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1904469 | positive regulation of tumor necrosis factor secretion |
| BP | IEA | GO:2000521 | negative regulation of immunological synapse formation |
| BP | IDA | GO:2001189 | negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
Gene expression in normal tissue: HAVCR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HAVCR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HAVCR2
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