MASTL
Summary: This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microtubule associated serine/threonine kinase like | MIM:608221 | Ensembl:ENSG00000120539 | HGNC:HGNC:19042 | PA134943781 | 10p12.1 |
GO terms in MASTL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007147 | female meiosis II |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:1904668 | positive regulation of ubiquitin protein ligase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0032154 | cleavage furrow |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | ISS | GO:0051721 | protein phosphatase 2A binding |
Gene expression in normal tissue: MASTL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MASTL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 5 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MASTL
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.