MASTL
Summary: This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608221 Ensembl IDEnsembl:ENSG00000120539 HGNC IDHGNC:HGNC:19042 PHARMGKB IDPA134943781 Map Location10p12.1 | |||||
GO terms in MASTL
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007147 | female meiosis II |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
Gene expression in normal tissue: MASTL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MASTL
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68875 | Mitotic Prophase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MASTL
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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