IKBKG

Summary: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinhibitor of nuclear factor kappa B kinase subunit gamma
OMIM IDMIM:300248
Ensembl IDEnsembl:ENSG00000269335
HGNC IDHGNC:HGNC:5961
PHARMGKB IDPA29777
Map LocationXq28

GO terms in IKBKG


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IPI GO:0019904 protein domain specific binding
MF IPI GO:0031625 ubiquitin protein ligase binding
MF IPI GO:0042802 identical protein binding
MF IDA GO:0042803 protein homodimerization activity
MF IEA GO:0042975 peroxisome proliferator activated receptor binding
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Gene expression in normal tissue: IKBKG

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in IKBKG


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Database
Pathway ID
Pathway Des.
pid bcr_5pathway BCR signaling pathway
pid cd8tcrpathway TCR signaling in naïve CD8+ T cells
pid faspathway FAS (CD95) signaling pathway
pid fcer1pathway Fc-epsilon receptor I signaling in mast cells
pid il1pathway IL1-mediated signaling events
pid nfkappabcanonicalpathway Canonical NF-kappaB pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IKBKG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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