PPFIA3
Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603144 Ensembl IDEnsembl:ENSG00000177380 HGNC IDHGNC:HGNC:9247 PHARMGKB IDPA33568 Map Location19q13.33 | |||||
GO terms in PPFIA3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0007269 | neurotransmitter secretion |
| BP | ISS | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| CC | IDA | GO:0001669 | acrosomal vesicle |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0048786 | presynaptic active zone |
| CC | ISS | GO:0098875 | epididymosome |
Gene expression in normal tissue: PPFIA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPFIA3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112310 | Neurotransmitter release cycle |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-181429 | Serotonin Neurotransmitter Release Cycle |
| reactome | R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle |
| reactome | R-HSA-210500 | Glutamate Neurotransmitter Release Cycle |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPFIA3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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