SCIN
Summary: SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| scinderin | MIM:613416 | Ensembl:ENSG00000006747 | HGNC:HGNC:21695 | PA134981389 | 7p21.3 |
GO terms in SCIN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001786 | phosphatidylserine binding |
| MF | ISS | GO:0003779 | actin binding |
| MF | TAS | GO:0003779 | actin binding |
| MF | ISS | GO:0005509 | calcium ion binding |
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | TAS | GO:0005545 | 1-phosphatidylinositol binding |
| MF | ISS | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | ISS | GO:0051015 | actin filament binding |
| CC | IEA | GO:0002102 | podosome |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005903 | brush border |
| CC | ISS | GO:0005938 | cell cortex |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0042995 | cell projection |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0017156 | calcium ion regulated exocytosis |
| BP | ISS | GO:0032330 | regulation of chondrocyte differentiation |
| BP | IMP | GO:0042989 | sequestering of actin monomers |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | ISS | GO:0045010 | actin nucleation |
| BP | IMP | GO:0045654 | positive regulation of megakaryocyte differentiation |
| BP | IMP | GO:0051014 | actin filament severing |
| BP | ISS | GO:0051047 | positive regulation of secretion |
| BP | IMP | GO:0051127 | positive regulation of actin nucleation |
| BP | IMP | GO:0051693 | actin filament capping |
Gene expression in normal tissue: SCIN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCIN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| wikipathways | WP474 | Endochondral Ossification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCIN
CLASSFICATION
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