PLPP2
Summary: The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607126 Ensembl IDEnsembl:ENSG00000141934 HGNC IDHGNC:HGNC:9230 PHARMGKB IDPA33554 Map Location19p13.3 | |||||
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PLPP2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008195 | phosphatidate phosphatase activity |
| MF | IBA | GO:0016791 | phosphatase activity |
| MF | TAS | GO:0042392 | sphingosine-1-phosphate phosphatase activity |
| MF | IBA | GO:0042577 | lipid phosphatase activity |
Gene expression in normal tissue: PLPP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLPP2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00039 | Glycerolipid Metabolism |
| smpdb | SMP00187 | Glycerol Kinase Deficiency |
| smpdb | SMP00529 | D-glyceric acidura |
| smpdb | SMP00530 | Familial lipoprotein lipase deficiency |
| wikipathways | WP325 | Triacylglyceride Synthesis |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLPP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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