CDK13
Summary: The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 13 | MIM:603309 | Ensembl:ENSG00000065883 | HGNC:HGNC:1733 | PA26264 | 7p14.1 |
GO terms in CDK13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IPI | GO:0002945 | cyclin K-CDK13 complex |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005694 | chromosome |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | ISS | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | ISS | GO:0000380 | alternative mRNA splicing, via spliceosome |
| BP | TAS | GO:0000380 | alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007088 | regulation of mitotic nuclear division |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0030097 | hemopoiesis |
| BP | IBA | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain |
| BP | IDA | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain |
| BP | IEA | GO:2000737 | negative regulation of stem cell differentiation |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity |
| MF | IDA | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0030332 | cyclin binding |
| MF | IPI | GO:0030332 | cyclin binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
Gene expression in normal tissue: CDK13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD780 | PP-30 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK13
CLASSFICATION
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