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CDK13

Summary: The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecyclin dependent kinase 13 OMIM IDMIM:603309 Ensembl IDEnsembl:ENSG00000065883 HGNC IDHGNC:HGNC:1733 PHARMGKB IDPA26264 Map Location7p14.1

Gene Categories:

DRUGGABLE GENOME TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE

GO terms in CDK13

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IBA	GO:0000790	nuclear chromatin
CC	IPI	GO:0002945	cyclin K-CDK13 complex
CC	TAS	GO:0005576	extracellular region
CC	HDA	GO:0005615	extracellular space
CC	IBA	GO:0005634	nucleus

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Gene expression in normal tissue: CDK13

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDK13

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes
reactome	R-HSA-6798695	Neutrophil degranulation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD779	PRL-3 Inhibitor I	3
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD670	ML 210	3
iGMDRD781	Sirolimus	5

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK13

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.