TP63
Summary: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tumor protein p63 | MIM:603273 | Ensembl:ENSG00000073282 | HGNC:HGNC:15979 | PA162406776 | 3q28 |
GO terms in TP63
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IMP | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0050699 | WW domain binding |
| MF | IPI | GO:0097371 | MDM2/MDM4 family protein binding |
| BP | IEA | GO:0001302 | replicative cell aging |
| BP | IEA | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001736 | establishment of planar polarity |
| BP | IEA | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | IEA | GO:0002064 | epithelial cell development |
| BP | IEA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007499 | ectoderm and mesoderm interaction |
| BP | IEA | GO:0009954 | proximal/distal pattern formation |
| BP | IEA | GO:0010259 | multicellular organism aging |
| BP | IEA | GO:0010481 | epidermal cell division |
| BP | ISS | GO:0010482 | regulation of epidermal cell division |
| BP | IEA | GO:0010838 | positive regulation of keratinocyte proliferation |
| BP | IEA | GO:0030216 | keratinocyte differentiation |
| BP | IEA | GO:0030859 | polarized epithelial cell differentiation |
| BP | IEA | GO:0031069 | hair follicle morphogenesis |
| BP | IEA | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway |
| BP | IEA | GO:0035115 | embryonic forelimb morphogenesis |
| BP | IEA | GO:0035116 | embryonic hindlimb morphogenesis |
| BP | IEA | GO:0036342 | post-anal tail morphogenesis |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0043589 | skin morphogenesis |
| BP | IEA | GO:0043616 | keratinocyte proliferation |
| BP | IEA | GO:0045617 | negative regulation of keratinocyte differentiation |
| BP | IMP | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IDA | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048485 | sympathetic nervous system development |
| BP | IEA | GO:0048745 | smooth muscle tissue development |
| BP | IEA | GO:0048807 | female genitalia morphogenesis |
| BP | IPI | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0051402 | neuron apoptotic process |
| BP | IEA | GO:0060157 | urinary bladder development |
| BP | IEA | GO:0060197 | cloacal septation |
| BP | IEA | GO:0060513 | prostatic bud formation |
| BP | IEA | GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development |
| BP | ISS | GO:0061436 | establishment of skin barrier |
| BP | TAS | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IEA | GO:1904674 | positive regulation of somatic stem cell population maintenance |
| BP | IEA | GO:1904888 | cranial skeletal system development |
| BP | IDA | GO:2000271 | positive regulation of fibroblast apoptotic process |
| BP | IEA | GO:2000381 | negative regulation of mesoderm development |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005791 | rough endoplasmic reticulum |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: TP63
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TP63
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-139915 | Activation of PUMA and translocation to mitochondria |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| reactome | R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| reactome | R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| reactome | R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands |
| reactome | R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| wikipathways | WP1742 | TP53 Network |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3655 | Hypothetical Craniofacial Development Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD139 | Fumagillol | 1 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD79 | Gemcitabine | 7 |
| iGMDRD523 | Cyanoquinoline, 11 | 11 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD499 | PDMP | 6 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD226 | ML006 | 5 |
| iGMDRD513 | BML-259 | 6 |
| iGMDRD640 | CAY10618 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD375 | GW-405833 | 5 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 4 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TP63
CLASSFICATION
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