TP63


Summary: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tumor protein p63MIM:603273Ensembl:ENSG00000073282HGNC:HGNC:15979PA1624067763q28

GO terms in TP63


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0000989transcription factor activity, transcription factor binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0002039p53 binding
MFNASGO:0003677DNA binding
MFIMPGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046872metal ion binding
MFIPIGO:0050699WW domain binding
MFIPIGO:0097371MDM2/MDM4 family protein binding
BPIEAGO:0001302replicative cell aging
BPIEAGO:0001501skeletal system development
BPIEAGO:0001736establishment of planar polarity
BPIEAGO:0002053positive regulation of mesenchymal cell proliferation
BPIEAGO:0002064epithelial cell development
BPIEAGO:0006338chromatin remodeling
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0006915apoptotic process
BPIEAGO:0007219Notch signaling pathway
BPIEAGO:0007283spermatogenesis
BPIEAGO:0007499ectoderm and mesoderm interaction
BPIEAGO:0009954proximal/distal pattern formation
BPIEAGO:0010259multicellular organism aging
BPIEAGO:0010481epidermal cell division
BPISSGO:0010482regulation of epidermal cell division
BPIEAGO:0010838positive regulation of keratinocyte proliferation
BPIEAGO:0030216keratinocyte differentiation
BPIEAGO:0030859polarized epithelial cell differentiation
BPIEAGO:0031069hair follicle morphogenesis
BPIEAGO:0033147negative regulation of intracellular estrogen receptor signaling pathway
BPIEAGO:0035115embryonic forelimb morphogenesis
BPIEAGO:0035116embryonic hindlimb morphogenesis
BPIEAGO:0036342post-anal tail morphogenesis
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPTASGO:0042981regulation of apoptotic process
BPIEAGO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0043589skin morphogenesis
BPIEAGO:0043616keratinocyte proliferation
BPIEAGO:0045617negative regulation of keratinocyte differentiation
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPIDAGO:0045747positive regulation of Notch signaling pathway
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048485sympathetic nervous system development
BPIEAGO:0048745smooth muscle tissue development
BPIEAGO:0048807female genitalia morphogenesis
BPIPIGO:0051289protein homotetramerization
BPIEAGO:0051402neuron apoptotic process
BPIEAGO:0060157urinary bladder development
BPIEAGO:0060197cloacal septation
BPIEAGO:0060513prostatic bud formation
BPIEAGO:0060529squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
BPISSGO:0061436establishment of skin barrier
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIEAGO:1904674positive regulation of somatic stem cell population maintenance
BPIEAGO:1904888cranial skeletal system development
BPIDAGO:2000271positive regulation of fibroblast apoptotic process
BPIEAGO:2000381negative regulation of mesoderm development
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIEAGO:0005791rough endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol

Gene expression in normal tissue: TP63

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TP63


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-139915Activation of PUMA and translocation to mitochondria
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
reactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and Caspases
reactomeR-HSA-6803211TP53 Regulates Transcription of Death Receptors and Ligands
reactomeR-HSA-6804759Regulation of TP53 Activity through Association with Co-factors
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
wikipathwaysWP1742TP53 Network
wikipathwaysWP254Apoptosis
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3655Hypothetical Craniofacial Development Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD267Oligomycin A1
iGMDRD415LE-1351
iGMDRD481Dactolisib1
iGMDRD434BMS-5369243
iGMDRD705Nakiterpiosin3
iGMDRD6AM-5804
iGMDRD105Triptolide2
iGMDRD139Fumagillol1
iGMDRD202Curcumin2
iGMDRD121GMX17784
iGMDRD103SN-382
iGMDRD322FK 8665
iGMDRD263AACOCF32
iGMDRD300Tozasertib1
iGMDRD505Pevonedistat3
iGMDRD329Merck602
iGMDRD662JQ-12
iGMDRD871BRD63682
iGMDRD367Ro 28-16753
iGMDRD79Gemcitabine7
iGMDRD523Cyanoquinoline, 1111
iGMDRD424Tamatinib1
iGMDRD512nutlin 35
iGMDRD123Isoevodiamine2
iGMDRD177Teniposide1
iGMDRD901ELCPK2
iGMDRD698Neratinib1
iGMDRD499PDMP6
iGMDRD870BRD636101
iGMDRD294Batimastat1
iGMDRD441TW 373
iGMDRD226ML0065
iGMDRD513BML-2596
iGMDRD640CAY106182
iGMDRD64Parbendazole3
iGMDRD780PP-301
iGMDRD887Compound 23 citrate2
iGMDRD188Piperlongumine1
iGMDRD781Sirolimus5
iGMDRD484Pluripotin4
iGMDRD779PRL-3 Inhibitor I2
iGMDRD427ABT7371
iGMDRD579PF7501
iGMDRD1008SR-II-138A2
iGMDRD151CHM-13
iGMDRD433Lexibulin2
iGMDRD126Tipifarnib4
iGMDRD375GW-4058335
iGMDRD748PHA-6657521
iGMDRD61Kinetin riboside3
iGMDRD193Fqi12
iGMDRD316N9-Isopropyl-olomoucine4
iGMDRD639YK 4-2792
iGMDRD446LY 21832402

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TP63

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