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RNASET2

Summary: This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ribonuclease T2	MIM:612944	Ensembl:ENSG00000026297	HGNC:HGNC:21686	PA128394541	6q27

Gene Categories:

DRUGGABLE GENOME

GO terms in RNASET2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003723	RNA binding
MF	IBA	GO:0004521	endoribonuclease activity
MF	IDA	GO:0004540	ribonuclease activity
MF	IEA	GO:0033897	ribonuclease T2 activity
BP	IBA	GO:0006401	RNA catabolic process
BP	IDA	GO:0006401	RNA catabolic process
BP	TAS	GO:0043312	neutrophil degranulation
BP	IEA	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
CC	IBA	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	HDA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space
CC	IDA	GO:0005764	lysosome
CC	IDA	GO:0005788	endoplasmic reticulum lumen
CC	TAS	GO:0035578	azurophil granule lumen
CC	IEA	GO:0043202	lysosomal lumen
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: RNASET2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RNASET2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-6798695	Neutrophil degranulation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASET2

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DATATYPES

CLASSFICATION

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