DCHS1
Summary: This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dachsous cadherin-related 1 | MIM:603057 | Ensembl:ENSG00000166341 | HGNC:HGNC:13681 | PA33000 | 11p15.4 |
GO terms in DCHS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005509 | calcium ion binding |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IMP | GO:0003192 | mitral valve formation |
| BP | IMP | GO:0003273 | cell migration involved in endocardial cushion formation |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | ISS | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0007389 | pattern specification process |
| BP | NAS | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0021915 | neural tube development |
| BP | ISS | GO:0022008 | neurogenesis |
| BP | ISS | GO:0035329 | hippo signaling |
| BP | IEA | GO:0036342 | post-anal tail morphogenesis |
| BP | IEA | GO:0043931 | ossification involved in bone maturation |
| BP | IEA | GO:0048565 | digestive tract development |
| BP | IEA | GO:0072137 | condensed mesenchymal cell proliferation |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:0090102 | cochlea development |
| CC | IEA | GO:0005622 | intracellular |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | NAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0045177 | apical part of cell |
Gene expression in normal tissue: DCHS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DCHS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04392 | Hippo signaling pathway - multiple species - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DCHS1
CLASSFICATION
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