DCHS1
Summary: This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603057 Ensembl IDEnsembl:ENSG00000166341 HGNC IDHGNC:HGNC:13681 PHARMGKB IDPA33000 Map Location11p15.4 | |||||
GO terms in DCHS1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005509 | calcium ion binding |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IMP | GO:0003192 | mitral valve formation |
| BP | IMP | GO:0003273 | cell migration involved in endocardial cushion formation |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | ISS | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
Gene expression in normal tissue: DCHS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DCHS1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04392 | Hippo signaling pathway - multiple species - Homo sapiens (human) |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DCHS1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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