DYNLL1
Summary: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601562 Ensembl IDEnsembl:ENSG00000088986 HGNC IDHGNC:HGNC:15476 PHARMGKB IDPA134972261 Map Location12q24.31 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in DYNLL1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IEA | GO:0030235 | nitric-oxide synthase regulator activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0045505 | dynein intermediate chain binding |
Gene expression in normal tissue: DYNLL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DYNLL1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
| biocarta | lis1pathway | lissencephaly gene (lis1) in neuronal migration and development |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111446 | Activation of BIM and translocation to mitochondria |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYNLL1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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