STX10
Summary: This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| syntaxin 10 | MIM:603765 | Ensembl:ENSG00000104915 | HGNC:HGNC:11428 | PA36228 | 19p13.13 |
GO terms in STX10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000149 | SNARE binding |
| MF | IBA | GO:0005484 | SNAP receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019905 | syntaxin binding |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0008021 | synaptic vesicle |
| CC | IBA | GO:0012505 | endomembrane system |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030285 | integral component of synaptic vesicle membrane |
| CC | IBA | GO:0031201 | SNARE complex |
| CC | IDA | GO:0031982 | vesicle |
| CC | TAS | GO:0032588 | trans-Golgi network membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0006906 | vesicle fusion |
| BP | IMP | GO:0032880 | regulation of protein localization |
| BP | IDA | GO:0034498 | early endosome to Golgi transport |
| BP | IBA | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | IDA | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | IBA | GO:0048278 | vesicle docking |
Gene expression in normal tissue: STX10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STX10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04130 | SNARE interactions in vesicular transport - Homo sapiens (human) |
| pharmgkb | PA162355621 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STX10
CLASSFICATION
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