TNFSF9
Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF superfamily member 9 | MIM:606182 | Ensembl:ENSG00000125657 | HGNC:HGNC:11939 | PA36629 | 19p13.3 |
GO terms in TNFSF9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IBA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IBA | GO:0045585 | positive regulation of cytotoxic T cell differentiation |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IBA | GO:0032813 | tumor necrosis factor receptor superfamily binding |
Gene expression in normal tissue: TNFSF9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFSF9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFSF9
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