TNFRSF11A
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 11a | MIM:603499 | Ensembl:ENSG00000141655 | HGNC:HGNC:11908 | PA36601 | 18q21.33 |
GO terms in TNFRSF11A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004888 | transmembrane signaling receptor activity |
| MF | ISS | GO:0005031 | tumor necrosis factor-activated receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019955 | cytokine binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0001503 | ossification |
| BP | IMP | GO:0002250 | adaptive immune response |
| BP | NAS | GO:0002548 | monocyte chemotaxis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009314 | response to radiation |
| BP | IMP | GO:0030316 | osteoclast differentiation |
| BP | ISS | GO:0032496 | response to lipopolysaccharide |
| BP | ISS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0034097 | response to cytokine |
| BP | ISS | GO:0034612 | response to tumor necrosis factor |
| BP | IMP | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IEA | GO:0045780 | positive regulation of bone resorption |
| BP | IEA | GO:0048535 | lymph node development |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | ISS | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0060086 | circadian temperature homeostasis |
| BP | IEA | GO:0060749 | mammary gland alveolus development |
| BP | ISS | GO:0070555 | response to interleukin-1 |
| BP | ISS | GO:0071812 | positive regulation of fever generation by positive regulation of prostaglandin secretion |
| BP | IMP | GO:0071847 | TNFSF11-mediated signaling pathway |
| BP | IMP | GO:0071848 | positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling |
| BP | IEA | GO:0072674 | multinuclear osteoclast differentiation |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
Gene expression in normal tissue: TNFRSF11A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF11A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| biocarta | ranklpathway | bone remodeling |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| netpath | Pathway_RANKL | RANKL |
| wikipathways | WP12 | Osteoclast Signaling |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF11A
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