TNFRSF10D


Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TNF receptor superfamily member 10dMIM:603614Ensembl:ENSG00000173530HGNC:HGNC:11907PA366008p21.3

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in TNFRSF10D


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004888transmembrane signaling receptor activity
MFIEAGO:0045569TRAIL binding
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPIEAGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0042981regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0050900leukocyte migration
CCTASGO:0005886plasma membrane

Gene expression in normal tissue: TNFRSF10D

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF10D


DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
pidp53downstreampathwayDirect p53 effectors
pidtrail_pathwayTRAIL signaling pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803211TP53 Regulates Transcription of Death Receptors and Ligands
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75158TRAIL signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF10D

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