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SUCLG2

Summary: This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namesuccinate-CoA ligase GDP-forming beta subunit OMIM IDMIM:603922 Ensembl IDEnsembl:ENSG00000172340 HGNC IDHGNC:HGNC:11450 PHARMGKB IDPA36247 Map Location3p14.1

GO terms in SUCLG2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	NAS	GO:0004776	succinate-CoA ligase (GDP-forming) activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0005525	GTP binding
MF	IEA	GO:0019003	GDP binding
MF	IEA	GO:0046872	metal ion binding

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Gene expression in normal tissue: SUCLG2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SUCLG2

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Database	Pathway ID	Pathway Des.
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2453	TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
wikipathways	WP78	TCA Cycle
smpdb	SMP00057	Citric Acid Cycle
smpdb	SMP00546	Congenital lactic acidosis
smpdb	SMP00547	Fumarase deficiency

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2
iGMDRD309	17AAG	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUCLG2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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